/ Dictionary / Index D despiteous: Meaning and Definition of Find definitions for: des•pit•e•ous Pronunciation: (di-spit'ē-us), [key] — adj. Archaic. malicious; spiteful. contemptuous. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. despiteful Des Plaines Related Content Daily Word Quiz: philtrum Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language