/ Dictionary / Index F frame-up: Meaning and Definition of Find definitions for: frame-up Pronunciation: (frām'up"), [key] — n. Informal. a fraudulent incrimination of an innocent person. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. See also: frame-up (Thesaurus) frameshift framework Related Content Daily Word Quiz: panacea Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language