/ Dictionary / Index H Holofernes: Meaning and Definition of Find definitions for: Hol•o•fer•nes Pronunciation: (hol"u-fûr'nēz, hō"lu-), [key] — n. (in the Book of Judith) a general, serving Nebuchadnezzar, who was killed by Judith. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. See also: holofernes (Thesaurus) holoenzyme hologamous Related Content Daily Word Quiz: simian Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language