/ Dictionary / Index O Opelika: Meaning and Definition of Find definitions for: O•pe•li•ka Pronunciation: (ō"pu-lī'ku), [key] — n. a city in E Alabama. 21,896. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. Op-Ed Opelousas Related Content Daily Word Quiz: lyceum Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language