/ Dictionary / Index O Opelousas: Meaning and Definition of Find definitions for: Op•e•lou•sas Pronunciation: (op"u-l'sus), [key] — n. a city in S Louisiana. 18,903. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. Opelika open Related Content Daily Word Quiz: panacea Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language