/ Dictionary / Index O opus: Meaning and Definition of Find definitions for: o•pus Pronunciation: (ō'pus), [key] — pl. o•pus•es o•pe•ra a musical composition. one of the compositions of a composer, usually numbered according to the order of publication. a literary work or composition, as a book:Abbr.: op. Have you read her latest opus? Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. See also: opus (Thesaurus) opulent opuscule Related Content Daily Word Quiz: blithesome Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language