/ Dictionary / Index P pick-me-up: Meaning and Definition of Find definitions for: pick-me-up Pronunciation: (pik'mē-up"), [key] — n. Informal. an alcoholic drink taken to restore one's energy or good spirits. any restorative, as a snack or coffee. Also called Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. See also: pick-me-up (Thesaurus) picklock pick-off Related Content Daily Word Quiz: foliage Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language