/ Dictionary / Index P prefrontal lobotomy: Meaning and Definition of Find definitions for: prefron'tal lobot'omy Pronunciation: [key] a psychosurgical procedure in which the frontal lobes are separated from the rest of the brain by cutting the connecting nerve fibers. Also called Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. prefrontal preggers Related Content Daily Word Quiz: simian Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language