/ Dictionary / Index S sign of the cross: Meaning and Definition of Find definitions for: sign' of the cross' Pronunciation: [key] a movement of the hand to indicate a cross, as from forehead to breast and left shoulder to right or, in the Eastern Orthodox Church, from right shoulder to left. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. sign-off sign of the zodiac Related Content Daily Word Quiz: tenacious Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language