/ Dictionary / Index S sign of the zodiac: Meaning and Definition of Find definitions for: sign' of the zo'diac Pronunciation: [key] — Astrol. Astrol. one of the twelve constellations along the path of the ecliptic. (in contemporary Western astrology) one of the twelve divisions of the ecliptic, each consisting of 30 degrees, marked off from the point of the vernal equinox. See illus. at Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. sign of the cross sign-on Related Content Daily Word Quiz: pudgy Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language