/ Dictionary / Index S splenomegaly: Meaning and Definition of Find definitions for: sple•no•meg•a•ly Pronunciation: (splē"nu-meg'u-lē, splen"u-), [key] — n. Pathol. enlargement of the spleen. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. See also: splenomegaly (Thesaurus) spleno- spleuchan Related Content Daily Word Quiz: neologism Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language