/ Dictionary / Index U Upington: Meaning and Definition of Find definitions for: Up•ing•ton Pronunciation: (up'ing-tun), [key] — n. a city in the N Cape of Good Hope province, in the N Republic of South Africa. 28,000. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. UPI Upjohn Related Content Daily Word Quiz: neologism Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language