/ Dictionary / Index S Sistine Chapel: Meaning and Definition of Find definitions for: Sis'tine Chap'el Pronunciation: [key] the chapel of the pope in the Vatican at Rome, built for Pope Sixtus IV and decorated with frescoes by Michelangelo and others. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. Sistine Sistine Madonna* Related Content Daily Word Quiz: perspicacious Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language