/ Dictionary / Index S Sistine Madonna*: Meaning and Definition of Find definitions for: Sis'tine Madon'na Pronunciation: [key] a Madonna painted by Raphael for the Church of St. Sixtus at Piacenza, Italy. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. Sistine Chapel sistrum Related Content Daily Word Quiz: neologism Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language